Best Hormone Pellet Therapy Companies for Clinics (2026): Biote and 6 More Compared

For physicians, NPs, PAs and practice owners adding hormone pellets. Updated October 22, 2026 · Prepared by Prospyr. Prospyr makes practice software, not hormones or pellet programs, and none of the companies below is a Prospyr product or partner. This guide compares Biote and six other hormone pellet companies that sell training, dosing tools, pellet supply and practice support to clinics. Each summary reflects what the company publishes on its own website (and, for Biote, its SEC filings), checked October 2026. This article is not medical, legal or pharmacy advice, and it makes no claim about the safety or effectiveness of any hormone product. Terms, prices and supply arrangements change, so confirm everything in writing before you sign or order.

What does a hormone pellet therapy company provide?

A hormone pellet therapy company gives a practice the pieces it needs to offer subcutaneous hormone pellets: provider training on its method, a dosing tool or protocol, access to compounded estradiol and testosterone pellets made by a pharmacy or FDA-registered 503B outsourcing facility, insertion supplies, and marketing and business support. Some, like Biote, EVEXIAS and SottoPelle, are full programs that certify providers and list them in a patient-facing directory. Others, like Wells Pharmacy Network and Belmar Pharma Solutions, are compounders that supply pellets to any prescriber with an account.

One fact applies to every company here. Custom-dosed hormone pellets are compounded drugs, and the FDA states plainly that "compounded drugs are not FDA-approved," meaning the agency does not review their safety, effectiveness or quality before they are sold (FDA compounding Q&A). Registration as a 503B outsourcing facility is not product approval. A separate product, Testopel (testosterone pellets for implantation, Endo), is listed on Drugs@FDA under ANDA 080911; it is not the custom-compounded pellet these programs describe.

If you are still choosing how to learn hormone therapy, start with our guide to hormone therapy training for providers, which compares vendor-neutral BHRT courses, medical society credentials and pellet courses. This page covers the companies you would buy from and work with after training.

The 7 hormone pellet therapy companies at a glance

How we chose this list

We searched for companies that sell hormone pellet programs or pellet supply to US practices, then loaded each company's own website. We kept companies that (1) were operating and taking new providers or accounts in October 2026, (2) describe what a practice gets, such as training, dosing tools, supply or support, and (3) explain how a practice signs up. We compared four things you can check before a sales call:

• Program or supplier. Does the company license a method and certify providers, or simply compound pellets for any prescriber?
• Where pellets come from. Does it name the 503A pharmacy or 503B outsourcing facility that makes them?
• Published terms. Are training fees, monthly fees and contract terms on the website?
• Support after launch. Mentors, medical directors, dosing review, marketing and directory listings.

We do not compare dosing methods, outcomes or side-effect rates, and nothing here is a dosing recommendation. Full programs are listed first, then compounders. The order is our editorial view, not a measure of quality or results.

1Biote#

Biote, based in Irving, Texas, trains and certifies providers in the Biote Method, its pellet-based bioidentical hormone replacement therapy (BHRT) program. Its parent, biote Corp., trades on Nasdaq under BTMD. Biote states it has trained more than 9,200 providers in more than 5,300 clinics and reports approximately 6 million pellet insertions in its history.

What stands out:

• Training and mentors. Biote lists one national and five regional training centers, 10 clinical faculty members and 66 clinical mentors, and pairs each certified provider with a Biote mentor for support on regulatory compliance, education and research updates.
• Dosing software. Its Biote Method Clinical DS is clinical decision support software that certified providers use for diagnosis, dosage and delivery method decisions.
• Pellet sourcing. Biote states its pellets come only from FDA-registered 503B outsourcing facilities and that it requires potency standards stricter than plus or minus 10%. Its Q2 2026 10-Q filing says a portion of pellets is made at its own 503B facility, Asteria Health, in Birmingham, Alabama, with supply agreements with AnazaoHealth and Carie Boyd, both FDA-registered 503B facilities.
• More than pellets. Biote also sells Biote-branded nutraceuticals and describes prescription peptide therapeutics.

Right for: practices that want a structured, widely recognized pellet program with assigned mentors and a patient-facing provider finder. Ask: the full cost of training and onboarding, any purchase minimums or contract term, whether you may use other dosing approaches, and how supply is handled. The same 10-Q describes a January 2026 voluntary recall of specific Asteria Health pellet lots and states Biote relies in part on third-party pellet suppliers.

Visit Biote →

2EVEXIAS (EvexiPEL)#

EVEXIAS Health Solutions, with a corporate office in Southlake, Texas, describes itself as the exclusive provider of EvexiPEL education and training, its proprietary method of bioidentical hormone pellet therapy. Its site lists on-site and off-site training on hormone balance, pellet insertion and nutraceuticals.

What stands out:

• Business support. Its Practice Growth and Business Support offer covers pricing and service bundles, marketing collateral and social media tools, patient communication scripts and email sequences, and compliance documentation.
• Practice Development Specialist. EVEXIAS assigns a Practice Development Specialist to work on a practice's business objectives.
• Wider catalog. It also offers peptide therapy, thyroid support and a nutraceutical line, plus an EvexiPEL provider directory for patients.

Right for: practices that want pellet training, supplements and business coaching from one company. Ask: which pharmacy or 503B facility makes EvexiPEL pellets (the pages we checked do not say), what you are required to purchase, the contract length and fees, which are not published.

Visit EVEXIAS (EvexiPEL) →

3SottoPelle#

SottoPelle, led by founder and CEO CarolAnn Tutera, teaches the SottoPelle Method of pellet therapy. Its site lists separate female, male and transgender hormone therapy training, a provider finder and the Dosaggio dosing calculator.

What stands out:

• Published training prices. Online training is listed at $1,745, and on-site or live virtual training at $2,500, each with a certificate of completion upon passing (as of October 2026).
• Published monthly plans. Every training package is paired with a support plan. The pricing page, under a "Pricing for Arizona Providers" heading, lists a Starter plan at $295 a month ($265 billed annually) with a 6-month license agreement, and a Standard plan at $495 a month ($445 billed annually) that adds a dedicated account manager, regular check-in calls and full marketing access.
• Supply through the plan. Plans include access to buy discounted pellets, trocars, recovery cream and SottoPelle's Caitera nutraceuticals.

Right for: providers who want to see training and ongoing costs before a sales call. Ask: whether plan prices differ outside Arizona, which pharmacy makes the pellets, and what happens to dosing calculator access if you cancel.

Visit SottoPelle →

4Pellecome#

Pellecome, in Gladstone, New Jersey, was started by Dr. Enrique G. Jacome, a board-certified OB-GYN who states he began using BHRT pellet implants in 2002. It pairs a two-part training course (online modules, then a live day with insertions on patients under a physician proctor) with its own patented Re3 Advanced Pellet Delivery System, a single-use insertion kit.

What stands out:

• Published license fee. Pellecome Advantage Licensing is listed at $199 a month (as of October 2026). Licensees get discounts on the Re3 kit, pellets and team training, a provider locator listing and marketing materials.
• Terms. Pellecome advertises "no contracts and no procedural fees" and "No Contracts & No Non-Competes," while its licensing page also names a BHRT Provider Practice Agreement.
• Physician portal. Licensees get a dosing calculator and direct access to Pellecome medical directors.

Right for: providers who want a monthly license without a long contract and supervised insertions during training. Ask: for the practice agreement in writing, the course fee, who compounds the pellets, and the Re3 kit price.

Visit Pellecome →

5Purepell (HTCA)#

Purepell, whose site runs on the domain of Hormone Therapy Centers of America (HTCA), describes a turnkey BHRT program for practices, clinics and med spas. It lists training, a dosing platform and inventory, a marketing media library, clinical and operational support, and lead generation tools, and says practices can begin treating patients in less than 30 days.

What stands out:

• Two-day training in Dallas. Purepell holds monthly new-provider training in Dallas, Texas, with classroom instruction followed by hands-on procedure training led by a Purepell medical director, including procedures on actual patients.
• Team training. Support team members get on-site training on best practices and marketing tools.
• Ongoing clinical help. Providers get clinical assistance from Purepell medical directors through its dosing site.

Right for: practices that want hands-on training on live patients and a single company for dosing, inventory and marketing. Ask: onboarding fees, timelines and per-provider costs (Purepell gives these on a call with an Executive Success Manager), and which facility compounds its pellets.

Visit Purepell (HTCA) →

6Wells Pharmacy Network#

Wells Pharmacy Network supplies compounded implantable BHRT pellets to prescribers through both 503A patient-specific compounding and FDA-registered 503B outsourcing facility capabilities across its network. It describes a dedicated pellet production facility and states each lot is tested for potency, sterility, endotoxin and dissolution. Its own page notes that compounded preparations "have not been evaluated or approved by the FDA for safety or efficacy."

What stands out:

• Pellet options. Testosterone in multiple strengths for men and women, stearic acid or cholesterol bases, and combination pellets, with the full list on its order form.
• Provider support. Account setup and ordering help, pharmacist guidance on formulation questions and a provider guide to download.
• No program license. Wells supplies pellets and wider hormone compounding; it does not sell a branded method.

Right for: trained providers who want a pellet supplier rather than a licensed program. Ask: which items come from 503A versus 503B, whether it ships to your state, and turnaround times. See our list of 503B outsourcing facilities for how to check a facility's FDA record.

Visit Wells Pharmacy Network →

7Belmar Pharma Solutions#

Belmar Pharma Solutions describes itself as a national 503A compounding pharmacy and 503B outsourcing facility, with 503B sites in Golden and Lakewood, Colorado. Its pellet page states Belmar compounds estradiol and testosterone pellet implants, and its site lets practices place office-use orders, submit patient prescriptions or open an account.

What stands out:

• Two ordering routes. Separate paths for office-use orders and patient-specific prescriptions.
• Provider resources. Pages on licensure and shipping, support for nurse practitioners and medication package inserts.

Right for: practices that want pellets from a large compounder alongside other hormone and wellness medications. Ask: which pellets are 503B office-use versus 503A patient-specific, shipping to your state, and lot testing documentation.

Visit Belmar Pharma Solutions →

Questions to ask any hormone pellet company

1. Who makes the pellets? Get the name of the 503A pharmacy or 503B outsourcing facility, then check it yourself on the FDA's outsourcing facility list. Our 503B outsourcing facilities guide explains how.
2. How do you explain FDA status to patients? Compounded pellets are not FDA-approved. Make sure your consent forms and marketing say so, and that no claim goes beyond what you can support.
3. What do I have to buy, and for how long? Get purchase minimums, monthly license fees, contract length and cancellation terms in writing.
4. Can I use my own clinical judgment? Ask whether the program requires its dosing tool or protocol, and what happens if your medical director disagrees.
5. What happens during a recall or shortage? Ask how you will be notified, how replacement stock is handled and who pays.
6. Does it fit my scope of practice? Who may prescribe and insert pellets, and under what supervision, varies by state. Testosterone is a Schedule III controlled substance, so DEA registration applies. Check with your state board and counsel.
7. Is the training enough for my malpractice carrier? Ask your carrier before you treat patients.

Where Prospyr fits

A pellet program runs on lab results, recurring visits every few months and careful records of what each patient received. Prospyr keeps that on one patient record: lab ordering for baseline and follow-up panels, the aesthetic EMR for charting each insertion, inventory management for pellet lots, and memberships to bill a hormone program on a schedule. Booking and two-way SMS reminders help patients return on time. To see it with your hormone service, book a practice demo.

Frequently asked questions

Are hormone pellets FDA-approved?

Custom-compounded estradiol and testosterone pellets, the kind most pellet programs use, are not FDA-approved. The FDA states that compounded drugs are not FDA-approved and are not reviewed for safety, effectiveness or quality before they are sold. Testopel, a testosterone pellet from Endo, is listed on Drugs@FDA as an approved product; it is a separate product with its own labeling.

What is Biote?

Biote is a Texas company that trains and certifies providers in its pellet-based hormone therapy method, supplies dosing software, mentors and pellets from 503B outsourcing facilities, and lists certified providers for patients. Its parent company, biote Corp., is publicly traded on Nasdaq.

What are the alternatives to Biote for a practice?

Other full pellet programs include EVEXIAS (EvexiPEL), SottoPelle, Pellecome and Purepell. Some trained providers skip a program license and order pellets directly from a compounder such as Wells Pharmacy Network or Belmar Pharma Solutions. Compare training, contract terms, pellet source and support before you choose.

How much does it cost to join a pellet program?

Most companies do not publish prices. SottoPelle lists training at $1,745 to $2,500 plus support plans of $265 to $495 a month, and Pellecome lists licensing at $199 a month, as of October 2026. Ask every company for the total first-year cost, including training, pellets, supplies and fees.

Do I need training before offering pellets?

Yes. Every program here requires its own training, and your state board and malpractice carrier set the real requirements. Compare options in our guide to hormone therapy training for providers.

Want your company considered?

We review this list quarterly. Companies that provide hormone pellet programs, training or pellet supply to practices can send their website and what they offer practices to info@prospyrmed.com. Inclusion is editorial and not paid.

Editorial scope

This list is based on each company's public website, Biote's SEC filings and FDA resources, checked October 2026 with AI-assisted research. Companies did not review this article before publication. It is not medical, legal or pharmacy advice, a comparison of product safety or results, or a substitute for checking pharmacy licensure, FDA records and your state's scope-of-practice rules. Read our methodology or report a correction.