Top 9 Mobile IV Therapy and IV Lounge Franchises in 2026

For prospective IV therapy owners. Updated October 2, 2026 · Prepared by Prospyr. Prospyr makes practice software, not franchises, and none of the brands below is a Prospyr product. Each summary reflects what the franchisor publishes on its own website, checked October 2026. Investment ranges come from the franchisor's own pages and change with each Franchise Disclosure Document (FDD), so confirm every figure in the current FDD and in writing before you sign.

What is an IV therapy franchise?

An IV therapy franchise is a licensed business model for delivering nurse-administered IV hydration and vitamin infusions under a brand's name, menu, protocols and marketing, in exchange for a franchise fee and ongoing royalties. Formats fall into three groups: storefront IV lounges (roughly 900 to 2,000 square feet), mobile territories where nurses travel to homes, offices and hotels, and add-on or "fractional" models bolted onto an existing clinic or gym. Every format still needs a medical director, licensed nurses and compliance with your state's medical and nursing rules.

The 9 mobile IV therapy and IV lounge franchises at a glance

How we chose this list

We included brands that sell IV therapy franchises on their own website and publish at least some of the information an owner needs on day one: format, investment range or capital requirement, and how clinical oversight works. We favored brands that offer a mobile or concierge option, since that is the fastest-growing way buyers enter this category, and then storefront brands with the most published detail. We left out multi-modality wellness franchises where IV is one service among many, and franchisors that only publish an older FDD. The order is our editorial view, not a measure of results or franchisee profitability.

1. Vida-Flo

Vida-Flo is headquartered in Atlanta and describes itself as founded in 2012 as the nation's first IV hydration clinic, reporting more than 1,000,000 treatments delivered. It franchises two models side by side.

What stands out:

• Two formats. A retail clinic of 900 to 2,000 square feet, or a Mobile On-The-Go territory where licensed registered nurses deliver IV therapy on location.
• Published ranges. $213K–$399K for a retail clinic with a $49K franchise fee; $76K–$194K for a mobile territory, with a territory fee of $49K–$95K that scales with population, as of October 2026.
• Named medical leadership. It lists Dr. Tyler Wheeler, a primary care sports medicine physician, as corporate medical director overseeing clinical standards and protocols.
• Regions. Expanding in the Mid-Atlantic, Southeast and Southwest.

Right for: buyers who want to start mobile at lower cost and keep the option of a clinic later. Ask: royalty and marketing fees (not published on the page), whether a mobile territory can convert to a clinic, and how your local medical director relationship is structured.

2. Hydrate IV Bar

Hydrate IV Bar was founded in 2016 in Colorado and has franchised since 2020. It reports 29 units across nine states, with 29 of 48 available territories sold, and states that treatments are given by registered nurses under a physician's direction, with a fractional chief medical officer.

What stands out:

• Two formats. A full-service spa, or the Hydrate IV Mini Bar for mobile, concierge or bolt-on use inside another business.
• Published terms. $50,000 franchise fee, 8% royalty, $150,000 liquid capital and $500,000 net worth. Investment runs $347,050–$577,600 for a spa and $97,300–$162,550 for a Mini Bar, as of October 2026.
• Published results. It reports 2025 gross sales ranging from $423,091 to $1,301,318, with an average of $749,904, 44% of revenue from memberships, and 18% average EBITDA. Confirm these against Item 19 of the FDD.
• Timeline. About seven months from application to opening.

Right for: buyers who want published unit economics before the first call. Ask: how many units the sales figures cover, and the Mini Bar's royalty and territory rules.

3. Advanced Mobile IV

Advanced Mobile IV franchises a mobile-only model that delivers IV therapy to patients' homes, offices and hotels. It requires $75,000 minimum liquid capital and offers hands-on, medical-oversight and investment-only ownership roles. It reports serving more than 100,000 customers and lists 24/7 customer support and same-day appointments. Its consumer menu, as published, includes energy IVs at $249, hangover recovery at $159, and NAD+ from $275 to $475, along with peptides and injections.

Right for: buyers who want no lease and a visit-based business. Ask: franchise fee, royalty and unit count (not published on the page), how nurse travel time and territory size are set, and which menu items are allowed in your state.

4. Prime IV Hydration & Wellness

Prime IV Hydration & Wellness reports 240+ locations open or in development across 42 states, the largest footprint on this list. It requires $150,000 minimum liquidity, says a location can run with as few as two medical staff, and positions the owner as overseeing operations rather than handling clinical work. It lists 12 IV therapies and recognition including Entrepreneur's Franchise 500 IV therapy category, and states locations follow "797 guidelines" for safety and quality control.

Right for: buyers who want a large system with many peers to call. Ask: the full investment range, franchise fee and royalty from the current FDD, how many locations are open versus in development, and how it supports medical director recruitment.

5. The DRIPBaR

The DRIPBaR sells franchises in the US and Canada and calls itself one of the most recognizable brands in IV vitamin therapy. Its US opportunity page publishes an investment range of $142,125 to $404,800 as of October 2026 and describes a cash-based business suited to semi-absentee owners.

Right for: owners who plan to hire a manager and clinical team rather than work the floor. Ask: franchise fee, royalty, unit count and closures from the FDD, and what "semi-absentee" means in weekly hours.

6. IV Nutrition

IV Nutrition franchises a single-unit clinic offering IV drips, injections and blood testing. It lists an investment range of $198,050 to $402,550 (2025 FDD, varies by state), with $250,000 minimum liquid capital and $500,000 net worth. Parts of the franchise page appear dated, including growth plans for 2022, so ask for current location counts.

Right for: buyers who want IV paired with baseline micronutrient testing in one clinic. Ask: current open and closed units, franchise fee and royalty, and who orders and reviews lab tests.

7. prosperIV

prosperIV franchises spa lounges offering IV drips and boosts under registered nurse supervision, with a mobile IV expansion option. Founded by Christina Broccoli in the Westchester area, it lists an investment of $181,000 to $353,250 and $100,000 minimum liquid capital, and accepts owners with or without a healthcare background.

Right for: buyers looking at a smaller, earlier-stage brand where they may get more founder attention. Ask: units open today, franchise fee and royalty, and how mobile service is licensed under the same territory.

8. Revival IV Lounge

Revival IV Lounge is a Florida brand listing 10+ locations around Orlando and Central Florida. Its FAQ lists a $160K–$270K investment and a $45,000 franchise fee covering onboarding, training, brand rights and site selection support. Franchisees hire licensed RNs, and corporate helps with medical director requirements. No healthcare background is required, and multi-unit territories are offered.

Right for: buyers who want a lower published entry cost and are comfortable with a regional brand. Ask: royalty, how many locations are franchised versus corporate, and support outside Florida.

9. IVitamin Plus

IVitamin is an Austin, Texas IV provider that reports 16 years in business, with lounges in Austin and mobile IV service. Its IVitamin Plus Fractional Franchise is built for existing wellness and medical practices rather than standalone locations: it advertises "all-in for $35K or less" and launch in 60 days or less, including IV menus, pharmacy guidelines, SOPs, staff training and a branded membership program.

Right for: an established clinic that already has IV-licensed staff. Its stated requirements are at least two years in business, 400 to 600+ monthly patients and $700K+ annual revenue. Ask: ongoing fees, whether this is a registered franchise in your state, and whether your existing practice software can stay in place.

Questions to ask any IV therapy franchise

1. Who is the medical director, and who pays them? Get the oversight model, standing orders and good-faith exam process in writing, and confirm it fits your state's medical and nursing board rules.
2. Can a non-physician own the business in my state? Some states restrict lay ownership of medical services. Ask what structure the franchisor uses and have a healthcare attorney confirm it.
3. Where do the IV bags and additives come from? Ask which pharmacy or supplier is required, and how compounded or mixed products are handled.
4. What does Item 19 show? The FDD must be given to you at least 14 calendar days before you sign or pay, under the FTC Franchise Rule. Read the financial performance section and how many units it covers.
5. How many units have closed or transferred? Call current and former owners listed in the FDD.
6. What insurance do I need? Mobile models need professional liability that covers nurses in patients' homes; see our IV and mobile injector insurance list.
7. What software am I required to use? Ask whether scheduling, charting and payments are mandated, and who owns the patient data.

Where Prospyr fits

Most IV franchises live on memberships and repeat visits, and mobile models add travel, nurse schedules and chart notes taken outside the clinic. Prospyr handles memberships and multi-location reporting for IV and wellness practices; if your franchisor allows owner-chosen software, or you run an independent IV lounge, book a practice demo.

Frequently asked questions

How much does it cost to open an IV therapy franchise?

Published ranges on this list run from $35K or less for a fractional add-on to $577,600 for a full spa build-out. Mobile territories typically cost less than storefront lounges: Vida-Flo lists $76K–$194K for mobile and Hydrate IV Bar lists $97,300–$162,550 for its Mini Bar. Your final number depends on rent, build-out and state licensing.

Do I need to be a nurse or doctor to own an IV therapy franchise?

Several brands on this list say no healthcare background is required. You will still need a licensed medical director and licensed nurses, and some states limit who can own a business that provides medical services, so check your state's rules before signing.

Is a mobile IV franchise better than an IV lounge?

Neither is better in general. Mobile models cost less to open and avoid a lease but depend on nurse travel time and territory size; lounges cost more but can see several patients at once. Ask each franchisor for unit results by format in the FDD.

What training do IV nurses need?

Requirements depend on your state's nursing board and the franchisor's protocols. Many owners send staff to an outside course as well; see our list of IV therapy certification courses.

Want your company considered?

We review this list quarterly. IV therapy franchisors that serve prospective owners can send their website and what they offer franchisees to info@prospyrmed.com; inclusion is editorial and not paid.

Editorial scope

This list is based on each franchisor's public website, checked October 2026 with AI-assisted research. Franchisors did not review this article before publication. It is not a guarantee of results, an offer to sell a franchise, or a substitute for reading the FDD, checking references, and confirming licensure with your state. Owners adding weight loss or functional medicine services may also find our lists of medical weight loss program curricula and functional medicine training programs useful. Read our methodology or report a correction.