Best Software for a Medical Weight Loss Clinic Offering GLP-1 Programs (2026): 6 Platforms Compared

The best software for a medical weight loss clinic offering GLP-1 programs is the one that runs the whole program on one patient record: the exam before the first prescription, e-prescribing, lab orders and results, recurring program billing, reminders for every injection or check-in visit, and inventory for anything you administer in the office. If the program sits inside an aesthetic practice, start with Prospyr or Aesthetic Record. If it is a dedicated medical or functional medicine clinic, start with OptiMantra or Cerbo. If most care is virtual and coaching-led, start with Healthie or Practice Better.

For owners, medical directors and practice managers at medical weight loss, wellness and aesthetic practices. Updated October 28, 2026 · Prepared by Prospyr. Prospyr makes practice software and is one of the six platforms compared. Competitor details come from each company's own website and help center, checked on the dates shown, and link to fuller comparisons. This page covers software, not clinical protocols or dosing; confirm prescribing and supervision rules with your state boards.

The short answer, by type of clinic

What a GLP-1 program needs from its software

1. An exam before the first prescription. Many prescription programs require a good faith exam before medication is prescribed. Check whether the exam can be requested from the chart and whether the result comes back to the same record.
2. E-prescribing from the chart. Prescriptions should go electronically to the patient's pharmacy from the record you already chart in. If any provider prescribes a controlled substance, such as phentermine (Schedule IV on the DEA's controlled substance list), the software must be certified for electronic prescriptions for controlled substances (EPCS), and on some platforms that is a separate fee or plan.
3. Labs in the chart. Metabolic panels and other baseline labs ordered from the chart, with results back in the same record.
4. Recurring program billing. Most GLP-1 programs are sold as a monthly program or membership. The software should bill automatically and handle failed cards, pauses and cancellations without a spreadsheet.
5. Reminders on the program's cadence. Weekly or monthly injection visits and check-ins get missed once the first month is over. Reminders should follow each program's schedule, not a single generic follow-up.
6. Inventory for what you administer. If injections happen in the office, product used should be deducted from inventory and tied to the visit where it was used.

How 6 platforms compare

Prices are list prices as published on each company's site: OptiMantra and Aesthetic Record re-checked October 28, 2026; Cerbo, Healthie and Practice Better October 2026; exam and lab details from our September and October 2026 research.

Prospyr: a GLP-1 program inside an aesthetic practice

Prospyr fits aesthetic and wellness practices that run a GLP-1 program alongside injectables and other treatments and want both on one patient record. From the chart, the team requests a Qualiphy telehealth exam and the result syncs back automatically, sends prescriptions electronically to the patient's pharmacy through DoseSpot, and orders metabolic labs with results returned to the same record. Programs bill as recurring memberships with member pricing, follow-up reminders go out on each treatment's own cadence, and injectables are tracked to the unit, tied to the appointment where they were used. Prospyr also runs its own telehealth video visits. Medical weight loss clinic software.

What to check: Prospyr is quoted after a demo, so ask for the full monthly cost at your provider count. The one case where it isn't the right fit today is a program that depends on insurance billing for visits.

OptiMantra: lowest published price for a prescribing clinic

OptiMantra suits dedicated medical and multi-modality wellness clinics that want labs, prescribing and memberships in one system at a published price. Its pricing page lists $99 a month for the first practitioner, $49 for each additional practitioner, $25 per clinical team member and no charge for clerical team members, with an eRx license including EPCS at $38 a month and two-way texting at $75 a month, no long-term commitment and 30 days' cancellation notice (checked October 28, 2026). Membership and package management and telehealth video are in the base feature list.

What to check: Virtual good faith exams run through Spakinect, and OptiMantra's help center has you open your own Spakinect account before it works. Prospyr vs OptiMantra.

Cerbo: deepest labs and prescribing

Cerbo suits functional medicine and hormone clinics where weight loss is one protocol among several. Its prescribing seat includes e-prescribing and EPCS for standard, controlled and compounded medications, and it connects two ways with Labcorp, Quest and specialty labs. It lists $281 a month per full-time prescribing provider, telemedicine at $27 per provider a month and a $1,195 setup fee that it is waiving for a limited time (October 2026).

What to check: Online booking is request-based, with each request accepted by your team, and bulk texting runs through separate accounts. Prospyr vs Cerbo.

Healthie: virtual-first programs

Healthie suits virtual GLP-1 programs built around nutrition, coaching and a patient app. Packages bill once, weekly, biweekly, monthly, quarterly or yearly and can bundle visits, programs, products and lab orders, and video visits are built in. Plans start at $19.99 a month, and DoseSpot e-prescribing is $40 per prescriber on Plus and up (October 2026).

What to check: Healthie's help center says controlled-substance prescribing is available only on its Enterprise plan. Prospyr vs Healthie.

Practice Better: coaching-led programs

Practice Better suits nutrition and coaching practices that run weight management as a program or course, mostly online. Memberships bill on a recurring schedule on Professional and up, labs run through Rupa Health, Evexia or Fullscript Labs, and DrFirst e-prescribing with EPCS is $49 a month per practitioner plus a $99 onboarding fee (October 2026).

What to check: Product inventory isn't documented, so an in-office injection program needs another way to track what's on the shelf. Prospyr vs Practice Better.

Aesthetic Record: an aesthetic EMR with prescribing as an add-on

Aesthetic Record suits med spas adding a weight loss line to an injectables business. It publishes $15 a month per login on Essentials and $19 on Accelerator, each with a $399 startup and onboarding fee, and lists e-prescribing separately at $31 to $45 a month per prescriber depending on EPCS and term (checked October 28, 2026). Inventory management and monthly treatment subscriptions are on Essentials.

What to check: Lab ordering for metabolic or wellness panels isn't documented on its site, and Qualiphy exams are pay-per-exam on the Accelerator plan. Prospyr vs Aesthetic Record.

Platforms that need a second system for prescribing

Some popular booking platforms don't prescribe. As of our September and October 2026 research, Jane lists US e-prescribing as still being built, and neither e-prescribing nor lab ordering appears on Mangomint's or Mindbody's sites. A GLP-1 program on one of them needs a separate prescribing and lab tool, which splits the patient record in two.

A note on compounded GLP-1s

If your program has used compounded semaglutide or tirzepatide, re-check your sourcing. FDA determined the tirzepatide shortage resolved on December 19, 2024 and the semaglutide shortage resolved on February 21, 2025, and the periods in which it said it would not take action against compounders making copies of them have ended (FDA). Software doesn't change those rules; check where your prescriptions go and confirm with your pharmacy and counsel.

Questions to ask in every demo

• Show a new patient going from intake to an exam, a prescription and a baseline lab order, all on one record.
• If any provider prescribes a controlled substance, show an EPCS prescription and tell us which plan includes it.
• Show a monthly program billing automatically, a failed card, a pause and a cancellation.
• Show reminders going out on our program's own visit schedule.
• If we inject in the office, show product used at a visit coming off inventory.
• Show a patient's weight and visit history over the whole program.
• What is the total monthly cost at our provider and team count, with every add-on we'd use?
• Who moves our charts, programs and memberships over, and what does it cost?

Where Prospyr fits

Prospyr is built for aesthetic and wellness practices. For a GLP-1 program it keeps the good faith exam, prescriptions, labs, memberships, follow-up reminders and unit-level inventory on the same patient record as the rest of the practice, and the Prospyr team moves your data over from your current system. See medical weight loss clinic software or compare wellness clinic EMRs.

Frequently asked questions

What is the best software for a medical weight loss clinic offering GLP-1 programs?

It depends on the clinic. Aesthetic practices adding a GLP-1 program usually start with Prospyr or Aesthetic Record, dedicated medical or wellness clinics with OptiMantra or Cerbo, and virtual-first programs with Healthie or Practice Better. Whichever you choose, the exam, prescriptions, labs, recurring billing and visit reminders should run on one patient record.

Do I need EPCS for a GLP-1 program?

Not for GLP-1 medications themselves, which are not on the DEA's controlled substance list. You need EPCS if any provider prescribes a controlled substance electronically, such as phentermine, which the DEA lists as Schedule IV. Check which plan includes it: Cerbo includes it in its prescribing seat, OptiMantra in its $38 eRx add-on, Practice Better in its $49 ePrescribe add-on, and Healthie only on Enterprise.

Which weight loss clinic software publishes its prices?

OptiMantra, Cerbo, Healthie, Practice Better and Aesthetic Record publish list prices. For a single prescribing practitioner, OptiMantra comes to about $137 a month with eRx and EPCS before texting and card processing (October 2026). Prospyr quotes after a demo.

Can Prospyr run a GLP-1 weight loss program?

Yes. Prospyr requests Qualiphy good faith exams from the chart with results synced back, sends prescriptions through DoseSpot, orders labs with results in the same record, bills programs as recurring memberships, sends reminders on each treatment's cadence and tracks injectables to the unit.

Sources

• Prospyr: Medical weight loss clinic software
• OptiMantra pricing (checked October 28, 2026)
• OptiMantra help center: Connect with Spakinect for virtual Good Faith Exams
• Cerbo pricing
• Healthie pricing
• Healthie help center: Controlled substances (EPCS)
• Practice Better pricing and ePrescribe
• Aesthetic Record pricing (checked October 28, 2026)
• Jane: Prescriptions guide
• DEA: Controlled substances, alphabetical order (PDF)
• FDA: Clarifies policies for compounders as national GLP-1 supply begins to stabilize

Editorial scope

This is a software buyer's guide written by Prospyr with AI-assisted research and drafting, checked against the sources above on October 28, 2026. Prospyr is one of the platforms compared. It is not legal or medical advice. Read our methodology or report a correction.